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Diazepam is N-demethylated by CYP3A4 and 2C19 on the active metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 to the active metabolite temazepam. N-desmethyldiazepam and temazepam are each even further metabolized to oxazepam. Temazepam and oxazepam are mostly eliminated by glucuronidation. Dosage ought to be individualized for maxim